18 results
(View BibTeX file of all listed publications)
2021
Slippery micropropellers penetrate the vitreous humor
(US20210170056A1), 2021 (patent)
Microparticles actively propel through the vitreous humour and reach the retina in porcine eyes. The slippery micro helical propellers are constructed by the combination of glancing angle deposition technique and the fusion of the slippery liquid layer. The magnetically propulsion in the vitreous humour relies on the matched size of the propeller to the collagen network of the vitreous, and the anti-adhesion coating of the collagen fiber bundles. Clinical optical coherence tomography observed the displacement of the slippery micropropellers through the vitreous to the macular area on the retina. The slippery micropropellers realize the controllable massive movements to the retina in 30 mins, while exerting the travelling distance of above one centimeter. The injection of the slippery micropropellers, the magnetically-powered controllable propulsion in the vitreous, and the optical coherence tomography imaging technique, constitute an intact method for rapid targeted ocular delivery, providing a promising approach towards ophthalmologic applications.
Magnetic field generator
Qiu, T., Fischer, P.
(US20210228298A1), 2021 (patent)
A magnetic field generator that comprises at least three groups of magnets, the magnetic moment of each magnet being rotatable about a rotation axis, wherein each group comprises at least two magnets, and each group has an orientation in the sense that the rotation axes of the magnetic moments of the magnets of the same group extend in the group's orientation. The orientations of the different groups are linearly independent.
2020
Propeller and method in which a propeller is set into motion
Qui, T., Fischer, P.
(US20200031010A1), 2020 (patent)
A method where a propeller is set into locomotion relative to a medium at least partially surrounding the propeller. An actuator induces a rotation of the propeller relative to the medium and about a rotational axis of the propeller, and the propeller converts its rotational movement into locomotion relative to the medium. The aspect ratio of at least one cross-section of the propeller is three or more. Also a helical or modifiedly helical propeller for converting rotational movement of the propeller into locomotion of the propeller relative to a medium at least partially surrounding the propeller, where the aspect ratio of at least one cross section of the propeller is three or more. And a method of producing a propeller, including the step of providing a plate extending along the helical axis, where the aspect ratio of at least one cross section of the plate is three or more.
A conjugate complex facilitating the transport of a cargo through a medium
Rothenstein, D., Bill, J., Fischer, P.
(US20200215202A1), 2020 (patent)
The present invention relates to conjugate complexes, comprising at least one biological entity, at least one cargo moiety, and at least one effector moiety that is capable of converting, degrading, and/or modifying a given medium, wherein the at least one cargo moiety and the at least one effector moiety are directly or indirectly coupled to the biological entity. The present invention further relates to uses thereof and methods for facilitating the transport of a cargo moiety through a given medium.
Method of producing a phantom and phantom
(US10573201B2), 2020 (patent)
The present invention relates to a method of producing a phantom resembling a human or animal organ or tissue, the phantom comprising at least one first region having at least one tissue like property and at least one cavity having a plurality of hollow branches connected thereto, with at least some of the plurality of hollow branches being formed such that they project into the first region having tissue like properties. The invention further relates to a method of making the first structure and to a corresponding phantom.
2019
Method and apparatus for fabricating a component
(EP3034281B1), 2019 (patent)
The invention relates to a method of fabricating a component having a one-, two- or three-dimensional geometry, wherein the shape of the component is obtained by utilizing an acoustic field and the effect of acoustic forces and by fixating a shape that forms in the acoustic field. This may be achieved by accumulating a material, like e. g. discrete particles in the pressure nodes formed by the acoustic field. Furthermore, the invention relates to an apparatus for fabricating a component, including an acoustic source device for forming an acoustic field that gives rise to a shape, including shapes formed by a particle distribution by acoustic forces, and a fixation device for fixating a shape of the particle distribution. Applications of the invention are available in the fields of fabricating materials with arbitrary shapes, e.g. for rapid prototyping purposes, and the assembly of materials.
Method of assessing the performance of a human or robot carrying out a medical procedure and assessment tool
Qiu, T., Adams, F., Miernik, A., Fischer, P.
(US20190130791A1), 2019 (patent)
2018
Ultrasonic actuator device and applications thereof
(US10008960B2), 2018 (patent)
ltrasonic actuator device (100) includes actuator arm arrangement (10) including first and second actuator sections (11,12), wherein the first section is arranged for coupling with support structure (50) and the second section is movable relative to the first section, and ultrasonic driver device (20) including at least one ultrasonic driver unit (21-28) coupled with at least one of first and second sections for driving actuator arm arrangement (10) and for providing movement of the second section relative to the first section, and wherein actuator arm arrangement (10) is movable with at least two degrees of freedom and the at least one ultrasonic driver unit includes an array of oscillating elements being arranged for creating an acoustic stream in an adjacent medium in response to application of ultrasound. Furthermore, an operational instrument including at least one ultrasonic actuator device (100) and a method of using the device are described.
Apparatus and method for creating a holographic ultrasound field in an object
Melde, K., Weber, P., Fischer, P.
(US20180341221A1), 2018 (patent)
An ultrasonic apparatus (100) for creating a holographic ultrasound field (1) comprises an ultrasound source device (10) being adapted for creating an ultrasound wave, and a transmission hologram device (20) having a transmission hologram (21) and an exposed acoustic emitter surface (22), said transmission hologram device (20) being acoustically coupled with the ultrasound source device (10) and being arranged for transmitting the ultrasound wave through the acoustic emitter surface (22) and creating the holographic ultrasound field in a surrounding space, wherein the acoustic emitter surface (22) is a smooth surface which do not influence the field distribution of the ultrasound wave. Furthermore, a method of creating a holographic ultrasound field in an object (3), wherein the ultrasonic apparatus (100) is used, and applications of the ultrasonic apparatus (100) are described.
2016
Method for encapsulating a nanostructure, coated nanostructure and use of a coated nanostructure
Jeong, H. H., Lee, T. C., Fischer, P.
(WO2016156148A1), 2016 (patent)
The present invention relates to a method for encapsulating a nanostructure, the method comprising the steps of: -providing a substrate; -forming a plug composed of plug material at said substrate; -forming a nanostructure (on or) at said plug; -forming a shell composed of at least one shell material on external surfaces of the nanostructure, with the at least one shell material covering said nanostructure and at least some of the plug material,whereby the shell and the plug encapsulate the nanostructure. The invention further relates to a coated nanostructure and to the use of a coated nanostructure.
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